Studies have shown pharmacological doses of testosterone to relax coronary arteries when injected intraluminally [39] and to produce modest but consistent improvement in exercise-induced angina and reverse associated ECG changes [40]. The mechanism of action is via blockade of calcium channels with effect of similar magnitude to nifedipine
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shared by Nathan Goodyear on 12 May 14
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Testosterone Deficiency, Cardiac Health, and Older Men - 0 views
www.hindawi.com/...143763
low T Testosterone obesity type II diabetes diabetes health wellness metabolic syndrome lipids cholesterol hypogonadism TDS testicular dysgenesis syndrome men male hormone hormones prostate cancer
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men with chronic stable angina pectoris, the ischaemic threshold increased after 4 weeks of TRT and a recent study demonstrates improvement continuing beyond 12 months [
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Studies have shown an inverse relationship between serum testosterone and fasting blood glucose and insulin levels
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Medications such as chronic analgesics, anticonvulsants, 5ARIs, and androgen ablation therapy are associated with increased risk of testosterone deficiency and insulin resistance
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Women with T2D or metabolic syndrome characteristically have low SHBG and high free testosterone
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The precise interaction between insulin resistance, visceral adiposity, and hypogonadism is, as yet, unclear but the important mechanisms are through increased aromatase production, raised leptin levels, and increase in inflammatory kinins
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Men should be encouraged to combine aerobic exercise with strength training. As muscle increases, glucose will be burned more efficiently and insulin levels will fall. A minimum of 30 minutes exercise three times weekly should be advised
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studies now clearly show that low testosterone leads to visceral obesity and metabolic syndrome and is also a consequence of obesity
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In the case of MMAS [43], a baseline total testosterone of less than 10.4 nmol/L was associated with a greater than 4-fold incidence of type 2 diabetes over the next 9 years
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Low testosterone predicts increased mortality and testosterone therapy improves survival in 587 men with type 2 diabetes
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A similar retrospective US study involved 1031 men with 372 on TRT. The cumulative mortality was 21% in the untreated group versus 10% ( ) in the treated group with the greatest effect in younger men and those with type 2 diabetes
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the presence of ED has been shown to be an independent risk factor, particularly in hypogonadal men, increasing the risk of cardiac events by over 50%
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A recent online publication on ischaemic heart disease mortality in men concluded optimal androgen levels are a biomarker for survival
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A recent 10 year study from Western Australia involving 3690 men followed up from 2001–2010 concluded that TT and FT levels in the normal range were associated with decreased all-cause and cardiovascular mortality, for the first time suggesting that both low and DHT are associated with all-cause mortality and higher levels of DHT reduced cardiovascular risk
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The effect of treatment with TRT reduced the mortality rate of treated cohort (8.4%) to that of the eugonadal group whereas the mortality for the untreated remained high at 19.2%
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Men with angiographically proven CAD (coronary artery disease) have significantly lower testosterone levels [29] compared to controls ( ) and there was a significant inverse relationship between the degree of CAD and TT (total testosterone) levels
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men treated with long acting testosterone showed highly significant reductions in TC, LDL, and triglycerides with increase in HDL, associated with significant reduction in weight, BMI, and visceral fat
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In some studies, a decline in diastolic blood pressure has been observed, after 3–9 months [24, 26] and in systolic blood pressure
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TRT has been shown to upregulate PDE5 [65] and enhance the effect of PDE5Is (now an accepted therapy for both ED and LUTS), it no longer seems logical to advice avoidance of TRT in men with mild to moderate BPH.
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Several meta-analyses have failed to show a link between TRT and development of prostate cancer [66] but some studies have shown a tendency for more aggressive prostate cancer in men with low testosterone
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low bioavailable testosterone and high SHBG were associated with a 4.9- and 3.2-fold risk of positive biopsy
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Current EAU, ISSAM, and BSSM guidance [1, 2] is that there is “no evidence TRT is associated with increased risk of prostate cancer or activation of subclinical cancer.”
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Men with prostate cancer, treated with androgen deprivation, develop an increase of fat mass with an altered lipid profile
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Erectile dysfunction is an established marker for future cardiovascular risk and the major presenting symptom leading to a diagnosis of low testosterone
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shared by Nathan Goodyear on 05 Oct 15
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Branched Chain Amino Acid Supplementation for Patients with Cirrhosis | Clinical Correl... - 0 views
www.clinicalcorrelations.org/?p=3544
BCCA branched chain amino acids liver cirrhosis hepatitis amino acids
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low level of BCAAs in patients with cirrhosis is hypothesized to be one of multiple factors responsible for development of hepatic encephalopathy
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supplementation of BCAAs is thought to facilitate ammonia detoxification by supporting synthesis of glutamine, one of the non-branched chain amino acids, in skeletal muscle and in the brain as well as diminishing the influx of AAAs across the blood-brain barrier
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oral BCAA supplementation is more useful in chronic encephalopathic patients than is parenteral BCAA supplementation in patients with acute encephalopathy
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Studies show that administration of amino acid formulas enriched with BCAAs can reduce protein loss, support protein synthesis, and improve nutritional status of patients with chronic liver disease
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Leucine has been shown to be the most effective of the BCAAs because it acts via multiple pathways to stimulate protein synthesis
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BCAAs (particularly leucine) help to reverse the catabolic, hyperglucagonemic state of cirrhosis both by stimulating insulin release from the pancreatic β cells and by decreasing insulin resistance allowing for better glucose utilization
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BCAA supplementation improves protein-energy malnutrition by improving utilization of glucose, thereby diminishing the drive for proteolysis, inhibiting protein breakdown, and stimulating protein synthesis
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Cirrhotic patients have impaired immune defense, characterized by defective phagocytic activity and impaired intracellular killing activity
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another effect of BCAA supplementation is improvement of phagocytic function of neutrophils and possibly improvement in natural killer T (NKT) cell lymphocyte activity
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BCAA supplementation may reduce the risk of infection in patients with advanced cirrhosis not only through improvement in protein-energy malnutrition but also by directly improving the function of the immune cells themselves
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A proposed mechanism for improved liver regeneration is the stimulatory effect of BCAAs (particularly leucine) on the secretion of hepatocyte growth factor by hepatic stellate cells
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BCAAs activate rapamycin signaling pathways which promotes albumin synthesis in the liver as well as protein and glycogen synthesis in muscle tissue
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Chemical improvement with BCAA treatment is demonstrated by recovery of serum albumin and lowering of serum bilirubin levels
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long-term oral BCAA supplementation was useful in staving off malnutrition and improving survival by preventing end-stage fatal complications of cirrhosis such as hepatic failure and gastrointestinal bleeding
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The incidence of death by any cause, development of liver cancer, rupture of esophageal varices, or progression to hepatic failure was decreased in the group that received BCAA supplementation
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Patients receiving BCAA supplementation also have a lower average hospital admission rate, better nutritional status, and better liver function tests
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BCAAs have been shown to mitigate hepatic encephalopathy, cachexia, and infection rates, complications associated with the progression of hepatic cirrhosis
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Highest levels are found in casein whey protein of dairy products and vegetables, such as corn and mushrooms. Other sources include egg albumin, beans, peanuts and brown rice bran
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Oral supplementation tends to provide a better hepatic supply of BCAAs for patients able to tolerate PO nutrition as compared with IV supplementation, especially when treating symptoms of hepatic encephalopathy
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Coadministration of BCAAs with carnitine and zinc has also been shown to increase ammonia metabolism further reducing the encephalopathic symptoms
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Cirrhotic patients benefit from eating frequent, small meals that prevent long fasts which place the patient in a catabolic state
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the best time for BCAA supplementation is at bedtime to improve the catabolic state during starvation in early morning fasting
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A late night nutritional snack reduces symptoms of weakness and fatigability, lowers postprandial hyperglycemia, increases skeletal muscle mass,[25] improves nitrogen balance, and increases serum albumin levels.[26] Nocturnal BCAAs even improve serum albumin in cirrhotic patients who show no improvement with daytime BCAAs
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Protein-energy malnutrition (PEM), with low serum albumin and low muscle mass, occurs in 65-90% of cases of advanced cirrhosis
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BCAAs are further depleted from the circulation due to increased uptake by skeletal muscles that use the BCAAs in the synthesis of glutamine, which is produced in order to clear the ammonia that is not cleared by the failing liver
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patients with chronic liver disease, particularly cirrhosis, routinely have decreased BCAAs and increased aromatic amino acids (AAAs) in their circulation
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Maintaining a higher serum albumin in patients with cirrhosis is associated with decreased mortality and improved quality of life
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shared by Nathan Goodyear on 03 Mar 15
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Testosterone and metabolic syndrome: a meta-analysis study. - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...20807333
Testosterone metabolic syndrome glucose HOMA triglycerides waist circumference HDL men male hormone hormones
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Men with metabolic syndrome have lower Testosterone levels when compared to "healthy" individuals. All men with MetS should have a full androgen analysis performed. This meta-analysis of 20 studies found Testosterone therapy reduced fasting glucose, HOMA, triglycerides, waist circumference by Testosterone in men with MetS. This study found that Testosterone therapy increased HDL as well.
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shared by Nathan Goodyear on 10 Mar 15
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The Evaluation of Serum Levels of Testosterone in Type 2 Diabetic Men and Its Relation ... - 0 views
www.ncbi.nlm.nih.gov/...PMC4347063
low t low Testosterone total testosterone free testosterone glucose cholesterol LDL HgbA1c SHBG Testosterone men male hormone diabetes
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Small study of 2 men with type II diabetes finds fasting glucose levels negatively correlate with total and free Testosterone levels, HgbA1c negatively correlated with SHBG only, total cholesterol and LDL negatively correlated with SHBG and total testosterone. The prevalence of type II diabetes was higher with low free Testosterone than total Testosterone, but both were statistically significant.
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shared by Nathan Goodyear on 15 Aug 14
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Effects of Long-Term Testosterone Therapy on Patients with "Diabesity": Results of Obse... - 0 views
www.hindawi.com/...683515
Testosterone therapy treatment men male hormone hormones diabetes hypogonadism health obese obesity glucose HgbA1c blood pressure hypertension CRP liver enzymes waist circumference low Testosterone low weight low T
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Correlation between elevated serum ferritin and HbA1c in type 2 diabetes mellitus - Int... - 0 views
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shared by Nathan Goodyear on 16 May 16
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The telomerase activator TA-65 elongates short telomeres and increases health span of a... - 0 views
www.ncbi.nlm.nih.gov/...PMC3627294
TA-65 telomere Telomerase telomerase activator aging natural wellness health
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a stable and enforced expression of telomerase leads to an improved health-span, accompanied by an extension of lifespan
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TA-65 administration during 4 months significantly improved the capacity to uptake glucose after a glucose pulse
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A disadvantage of mTERT potentiation could be associated to its capacity to favor proliferation of cancerous cells in murine models
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TA-65 treated mice presented a similar incidence of malignant cancers at time of death, with a tendency to show decreased sarcomas and slightly increased lymphomas
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We demonstrate here that TA-65 leads to a significant rescue of short telomeres through telomerase activation
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TA-65 treatment increases proliferation and mobilization potential of mouse keratinocytes in vitro, a situation mimicking telomerase overexpression
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TAT2, a similar molecule, have beneficial effects in the activation of CD8+ T lymphocytes from HIV-infected patients where they observe an increase of the proliferative potential and enhancement of cytokine/chemokine production
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TA-65 resulted in a similar rescue of short telomeres in leukocytes post-treatment as observed with humans, most likely through an activation of telomerase
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we observe that TA-65 lead to 10 fold increase of telomerase RNA levels in the liver of treated mice comparing to the non-treated same-age cohorts
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TA-65 regulates telomerase at the transcription level, probably through the regulation of the MAPK pathway
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TA-65 dependent telomerase activation results in a better organ fitness as demonstrated by the improved scores at the glucose tolerance test and insulin levels at fasting
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TA-65 supplemented mice also present modest enhancement of the subcutaneous and epidermal thickness, as well as higher bone density, representative of an overall fitness status improvemen
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improved health-span of TA-65 treated mice is not accompanied by increased cancer incidence, which may be related to the fact that TERT levels are very modestly increased in all tissues tested except for the liver
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systemic telomerase overexpression from the germline leads to protection from aging associated pathologies
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similar situation could be mimicked expressing telomerase late in life in a telomerase deficient background
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we observed a higher proliferation rate and a partial protection from cell death in some tissues of TA65 treated mice
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shared by Nathan Goodyear on 04 Mar 15
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Fifty- two-Week Treatment With Diet and Exercise Plus Transdermal Testosterone Reverses... - 0 views
onlinelibrary.wiley.com/...full
diet exercise nutrition diabetes metabolic syndrome men male hormone hormones low T low Testosterone
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there appears to be a positive correlation between serum testosterone levels and insulin sensitivity in men across the full spectrum of glucose tolerance (Pitteloud et al, 2005), and this relationship is at least partially direct and not fully dependent on (changes in) elements of the MetS
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supervised D&E alone led to significant improvements in testosterone concentrations, glycemic control, and components of the MetS
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diet control, exercise, and testosterone supplementation may be beneficial in the management of men with T2D
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androgen-deprivation therapy in males with prostatic cancer may be associated with an increased risk for T2D, which may be caused by negative effects on insulin sensitivity
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insulin sensitivity, measured by HOMA, improved in both groups and with a significantly greater degree when testosterone was added to supervised D&E
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Fasting insulin concentrations, a good representative of insulin sensitivity, did show a significant correlation with changes in circulating androgen levels, an observation in support of Pitteloud et al (2005), who showed a direct relationship between insulin sensitivity and circulating testosterone concentrations using the hyper-insulinemic euglycemic clamp technique
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52 weeks of testosterone treatment also significantly improved circulation levels of adiponectin and hsCRP, key serum markers of insulin sensitivity and hepatic steatosis
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The changes in both adiponectin and hsCRP were significantly correlated with the therapy-induced changes in bioavailable testosterone
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serum PSA concentrations did not differ between the 2 treatment groups, indicating that short-term testosterone administration appears to be acceptably safe
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shared by Nathan Goodyear on 03 Feb 14
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The effects of compounded bioident... [Int J Pharm Compd. 2013 Jan-Feb] - PubMed - NCBI - 1 views
www.ncbi.nlm.nih.gov/...23627249
bioidentical hormone hormones menopause peri-menopause progesterone Bi-est DHEA Testosterone women
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Nan Sprouse liked it
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3 year study finds improvement in classic menopausal symptoms for women in perimenopause and menopause with improvement in other parameters: fasting glucose, cholesterol, MMP-9, CRP, fibrinogen and other clotting factors. This study used bioidentical Bi-est, progesterone, and in some DHEA and Testosterone.
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shared by Nathan Goodyear on 06 Aug 13
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Singapore Medical Association (SMA) - Formed in 1959, the Singapore Medical Association... - 0 views
sma.org.sg/...articles.aspx
type II diabetes Diabetes DM omega 3 EPA HbA1C HgbA1C insulin sensitivity insulin resistance insulin
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shared by Nathan Goodyear on 23 Mar 15
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A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Incre... - 0 views
jn.nutrition.org/...177S.abstract
nutrition diet high fat diet low carb diet fats carbohydrates weight fat fat mass insulin resistance obesity diabetes TNF-alpha insulin sensitivity
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THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: result... - 0 views
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Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death - NEJM - 0 views
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diabetes is associated with substantial premature death from several cancers, infectious diseases, external causes, intentional self-harm, and degenerative disorders, independent of several major risk factors
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shared by Nathan Goodyear on 03 Mar 14
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Testosterone deficiency syndrome and cardiovascular health: An assessment of beliefs, k... - 0 views
www.ncbi.nlm.nih.gov/...PMC3929476
low T Testosterone cardiovascular disease physicians men male hormone hormones
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Testosterone deficiency has a prevalence of 7% in the general population, rising to 20% in elderly males
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Males with CAD have lower testosterone levels than those with normal coronary angiograms of the same age,5 suggesting that the prevalence of testosterone deficiency is much higher in the CAD population
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Men with hypertension, another established risk factor for CAD, have lower testosterone compared to normotensive men
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Recent meta-analyses showed that testosterone levels are generally lower among patients with metabolic syndrome, regardless of the various definitions of metabolic syndrome that are used
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Testosterone (total and bioavailable) and sex-hormone binding globulin (SHBG) are inversely associated with the prevalence of metabolic syndrome in men between the ages of 40 and 80, and this association persists across racial and ethnic backgrounds
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Low testosterone levels have been related to increased insulin resistance and cardiovascular mortality,12 even in the absence of overt type 2 diabetes mellitus.
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testosterone levels (total and bioavailable) in middle-aged men are inversely correlated with insulin resistance
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The Massachusetts Male Aging Study (MMAS) demonstrated that low levels of testosterone and SHBG are independent risk factors for the development of type 2 diabetes,
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There is an inverse linear correlation between body mass index (BMI) and wait-to-hip ratio with testosterone and insulin-like growth factor-1 levels.
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Testosterone supplementation for 1 year in hypogonadal men has been shown to cause a significant improvement in body weight, BMI, waist size, lipid profile, and C-reactive protein levels
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TRT for 3 months in hypogonadal men with type 2 diabetes significantly improved fasting insulin sensitivity, fasting blood glucose and glycated hemoglobin.
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Testosterone replacement can improve angina symptoms and delay the onset of cardiac ischemia, likely through a coronary vasodilator mechanism
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ADT is associated with an increased risk of cardiovascular events, including myocardial infarction and cardiovascular mortality.
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ADT significantly increases fat mass, decreases lean body mass,29,30 increases fasting plasma insulin and decreases insulin sensitivity31 and increases serum cholesterol and triglyceride levels
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Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada. Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone. A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance. The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies. This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.
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shared by Nathan Goodyear on 20 Jan 11
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Cambridge Journals Online - Abstract - Effects of whey protein isolate on body composit... - 0 views
journals.cambridge.org/...displayAbstract
Whey protein elevated cholesterol insulin resistance diabetes
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The present study demonstrated that supplementation with whey proteins improves fasting lipids and insulin levels in overweight and obese individuals.
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shared by Nathan Goodyear on 07 Apr 14
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Association of fructose consumption and components... [Nutrition. 2014] - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...24698343
metabolic syndrome fructose nutrition diet glucose triglycerides hypertension
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shared by Nathan Goodyear on 23 Feb 15
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N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis o... - 0 views
www.ncbi.nlm.nih.gov/...PMC4306416
NAC N-acetylcysteine PCOS infertility women women's health female hormone hormones
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NAC significantly improved rates of live births and spontaneous ovulation compared to placebo in women with PCOS
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we found no evidence of effects of NAC on improving menstrual regularity, acne, hirsutism, BMI, fasting insulin, fasting glucose, or HOMA-IR
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NAC was not associated with greater benefits to metformin for improving pregnancy rate, spontaneous ovulations, and menstrual regularity
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Metformin also improved the BMI, total testosterone, insulin level, and lipid levels compared to NAC
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Data review finds NAC improves pregnancy rates and ovulation rates in women with PCOS against placebo. Meta-analysis revealed limited studies on the topic. When compared to metformin, there was no difference found. Though, one wonders if attacking insulin resistance through proper diet and additional neutraceutical approach would negate that. The reason? NAC and metformin are working in different biochemical pathways. The authors here seem to not realize this. It appears that they think NAC and metormin are both working in the same manner, but they don't. The fact that there is still benefit found compared to placebo, despited the authors lack of understanding of what NAC is and does is a positive.